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An Insightful Q&A with Fran Gregory, VP of Emerging Therapies at Cardinal Health, on the Outlook of Cell and Gene Therapy

Cell and gene therapy have emerged as promising fields in the healthcare industry, offering potential cures for previously untreatable diseases. To gain more insight into the outlook of these therapies, we had the opportunity to interview Fran Gregory, Vice President of Emerging Therapies at Cardinal Health. With her extensive experience in the industry, Gregory provided valuable insights into the current state and future prospects of cell and gene therapy.

Q: Can you provide an overview of the current landscape of cell and gene therapy?

A: Cell and gene therapy have gained significant attention in recent years due to their potential to revolutionize healthcare. These therapies involve using a patient’s own cells or modifying their genes to treat or cure diseases. Currently, there are several approved cell and gene therapies on the market, such as CAR-T cell therapies for certain types of cancer. However, the field is still in its early stages, with ongoing research and development to expand the range of treatable conditions.

Q: What are some of the challenges faced by cell and gene therapy developers?

A: One of the main challenges is the complexity and cost associated with manufacturing these therapies. Unlike traditional pharmaceuticals, cell and gene therapies require personalized production for each patient, making scalability a significant hurdle. Additionally, ensuring the quality, safety, and efficacy of these therapies throughout the manufacturing process is crucial. Regulatory frameworks are also evolving to keep pace with the rapid advancements in this field.

Q: How do you see the future of cell and gene therapy evolving?

A: The future of cell and gene therapy looks promising. As technology advances and manufacturing processes become more efficient, we can expect increased accessibility and affordability of these therapies. This will enable a broader range of patients to benefit from these treatments. Moreover, ongoing research is exploring the potential of cell and gene therapy in various disease areas beyond oncology, including genetic disorders, cardiovascular diseases, and neurodegenerative conditions.

Q: What role does Cardinal Health play in the cell and gene therapy space?

A: Cardinal Health is committed to supporting the development and commercialization of cell and gene therapies. We provide comprehensive solutions to help manufacturers navigate the complexities of the supply chain, from sourcing raw materials to delivering finished therapies to healthcare providers. Our expertise in logistics, distribution, and patient support services ensures that these therapies reach patients safely and efficiently.

Q: What are some of the key considerations for healthcare providers and payers when adopting cell and gene therapies?

A: Healthcare providers and payers need to consider several factors when adopting cell and gene therapies. Firstly, they must assess the clinical evidence supporting the therapy’s efficacy and safety. Additionally, the cost-effectiveness of these treatments compared to existing alternatives is a crucial consideration. As these therapies often require specialized infrastructure and expertise, providers must evaluate their capabilities to deliver these treatments effectively. Payers also need to develop reimbursement models that ensure patient access while maintaining sustainability.

Q: Are there any emerging trends or innovations in cell and gene therapy that you find particularly exciting?

A: One exciting trend is the development of off-the-shelf cell therapies. These therapies utilize donor cells instead of a patient’s own cells, eliminating the need for personalized manufacturing. This approach has the potential to significantly reduce costs and increase accessibility. Additionally, advancements in gene editing technologies like CRISPR-Cas9 offer new possibilities for precise genetic modifications, opening doors to treat a wider range of diseases.

Q: What advice would you give to aspiring professionals interested in pursuing a career in cell and gene therapy?

A: My advice would be to stay curious and embrace continuous learning. The field of cell and gene therapy is rapidly evolving, and professionals need to stay updated with the latest scientific advancements, regulatory changes, and manufacturing technologies. Building a strong network within the industry is also crucial for collaboration and staying informed about emerging opportunities. Lastly, having a passion for improving patient outcomes and making a difference in healthcare is essential for success in this field.

In conclusion, cell and gene therapy hold immense potential to transform the treatment landscape for various diseases. With ongoing advancements in technology, manufacturing processes, and regulatory frameworks, these therapies are poised to become more accessible and effective. As the industry continues to evolve, the insights shared by Fran Gregory provide a valuable perspective on the current state and future outlook of cell and gene therapy.

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