{"id":2531235,"date":"2023-03-30T11:31:27","date_gmt":"2023-03-30T15:31:27","guid":{"rendered":"https:\/\/platoai.gbaglobal.org\/platowire\/the-fragmentation-of-our-genes-the-role-of-a-dna-parasite-explained\/"},"modified":"2023-03-30T11:31:27","modified_gmt":"2023-03-30T15:31:27","slug":"the-fragmentation-of-our-genes-the-role-of-a-dna-parasite-explained","status":"publish","type":"platowire","link":"https:\/\/platoai.gbaglobal.org\/platowire\/the-fragmentation-of-our-genes-the-role-of-a-dna-parasite-explained\/","title":{"rendered":"The Fragmentation of Our Genes: The Role of a DNA ‘Parasite’ Explained"},"content":{"rendered":"

The human genome is a complex network of genes that work together to control the functioning of our bodies. However, recent research has shown that our genes are not as stable as we once thought. In fact, a DNA ‘parasite’ called a transposable element (TE) has been found to be responsible for the fragmentation of our genes.<\/p>\n

Transposable elements are segments of DNA that can move around the genome, inserting themselves into new locations. They were first discovered in the 1940s by Barbara McClintock, who won the Nobel Prize in Physiology or Medicine in 1983 for her work on transposable elements in maize. Since then, TEs have been found in almost all organisms, including humans.<\/p>\n

There are two main types of TEs: retrotransposons and DNA transposons. Retrotransposons use a copy-and-paste mechanism to move around the genome, while DNA transposons use a cut-and-paste mechanism. Both types of TEs can cause mutations in genes when they insert themselves into new locations.<\/p>\n

TEs were once thought to be ‘junk DNA’ with no function, but recent research has shown that they play an important role in the evolution of genomes. TEs can create new genes by inserting themselves into non-coding regions of the genome and providing new regulatory elements. They can also disrupt existing genes, leading to disease.<\/p>\n

One example of a TE that causes disease is the Alu element. Alu elements are a type of retrotransposon that make up about 10% of the human genome. They are responsible for the fragmentation of many genes, including the gene that causes spinal muscular atrophy (SMA). SMA is a genetic disorder that affects the muscles used for movement, and is the leading genetic cause of infant mortality.<\/p>\n

Alu elements can disrupt genes by inserting themselves into introns, which are non-coding regions of genes. This can cause alternative splicing, where different parts of the gene are spliced together in different ways, leading to a non-functional protein. Alternatively, Alu elements can cause exonization, where non-coding regions of the gene are spliced into the mRNA, leading to a non-functional protein.<\/p>\n

TEs are not all bad, however. They have played an important role in the evolution of genomes, and can provide new regulatory elements that allow organisms to adapt to changing environments. TEs have also been used as tools in genetic engineering, where they are used to insert new genes into the genome.<\/p>\n

In conclusion, the fragmentation of our genes is a complex process that is influenced by many factors, including transposable elements. TEs can cause mutations in genes, leading to disease, but they can also create new genes and provide new regulatory elements that allow organisms to adapt to changing environments. Understanding the role of TEs in genome evolution is an important area of research that has implications for human health and genetic engineering.<\/p>\n