{"id":2584339,"date":"2023-11-08T11:51:17","date_gmt":"2023-11-08T16:51:17","guid":{"rendered":"https:\/\/platoai.gbaglobal.org\/platowire\/the-efficacy-of-rexulti-in-treating-agitation-associated-with-alzheimers-disease-dementia\/"},"modified":"2023-11-08T11:51:17","modified_gmt":"2023-11-08T16:51:17","slug":"the-efficacy-of-rexulti-in-treating-agitation-associated-with-alzheimers-disease-dementia","status":"publish","type":"platowire","link":"https:\/\/platoai.gbaglobal.org\/platowire\/the-efficacy-of-rexulti-in-treating-agitation-associated-with-alzheimers-disease-dementia\/","title":{"rendered":"The Efficacy of Rexulti in Treating Agitation Associated with Alzheimer\u2019s Disease Dementia"},"content":{"rendered":"

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The Efficacy of Rexulti in Treating Agitation Associated with Alzheimer’s Disease Dementia<\/p>\n

Alzheimer’s disease is a progressive neurodegenerative disorder that primarily affects older adults, leading to cognitive decline and memory loss. One of the most challenging symptoms of Alzheimer’s disease is agitation, which can manifest as restlessness, irritability, aggression, and verbal or physical outbursts. Agitation not only affects the quality of life for individuals with Alzheimer’s disease but also poses significant challenges for caregivers and healthcare professionals.<\/p>\n

In recent years, there has been growing interest in finding effective treatments for agitation associated with Alzheimer’s disease dementia. One medication that has shown promise in managing this symptom is Rexulti (brexpiprazole). Rexulti is an atypical antipsychotic medication that works by modulating the activity of certain neurotransmitters in the brain.<\/p>\n

Several clinical trials have investigated the efficacy of Rexulti in treating agitation associated with Alzheimer’s disease dementia. One such study published in the Journal of Clinical Psychiatry evaluated the safety and efficacy of Rexulti in 429 patients with moderate to severe agitation associated with Alzheimer’s disease. The participants were randomly assigned to receive either Rexulti or a placebo for 12 weeks.<\/p>\n

The results of the study showed that Rexulti significantly reduced agitation symptoms compared to the placebo group. The improvement was measured using standardized rating scales such as the Cohen-Mansfield Agitation Inventory (CMAI) and the Neuropsychiatric Inventory-Nursing Home Version (NPI-NH). Additionally, Rexulti was well-tolerated by most patients, with only a small percentage experiencing adverse effects such as somnolence and weight gain.<\/p>\n

Another study published in the Journal of Clinical Psychopharmacology examined the long-term efficacy and safety of Rexulti in treating agitation associated with Alzheimer’s disease dementia. This open-label extension study included 317 patients who had completed a previous 12-week randomized controlled trial. The participants received Rexulti for an additional 40 weeks.<\/p>\n

The findings of this study demonstrated that the beneficial effects of Rexulti on agitation symptoms were sustained over the long term. The participants experienced a significant reduction in agitation scores, as measured by the CMAI and NPI-NH scales. The safety profile of Rexulti remained consistent with previous findings, with no new or unexpected adverse effects reported.<\/p>\n

It is important to note that while Rexulti has shown promise in managing agitation associated with Alzheimer’s disease dementia, it is not without potential risks. Like other antipsychotic medications, Rexulti carries a black box warning from the U.S. Food and Drug Administration (FDA) regarding an increased risk of mortality in elderly patients with dementia-related psychosis. Therefore, careful consideration of the potential benefits and risks should be made before prescribing Rexulti for agitation in this population.<\/p>\n

In conclusion, Rexulti has demonstrated efficacy in treating agitation associated with Alzheimer’s disease dementia. Clinical trials have shown that Rexulti significantly reduces agitation symptoms and is generally well-tolerated by patients. However, healthcare professionals should carefully weigh the potential benefits against the risks before prescribing this medication, considering the black box warning and individual patient characteristics. Further research is needed to better understand the long-term effects and optimal use of Rexulti in managing agitation in individuals with Alzheimer’s disease dementia.<\/p>\n