{"id":2589665,"date":"2023-11-22T09:00:00","date_gmt":"2023-11-22T14:00:00","guid":{"rendered":"https:\/\/platoai.gbaglobal.org\/platowire\/comparing-apellis-syfovre-and-astellas-izervay-a-comparison-of-geographic-atrophy-treatments\/"},"modified":"2023-11-22T09:00:00","modified_gmt":"2023-11-22T14:00:00","slug":"comparing-apellis-syfovre-and-astellas-izervay-a-comparison-of-geographic-atrophy-treatments","status":"publish","type":"platowire","link":"https:\/\/platoai.gbaglobal.org\/platowire\/comparing-apellis-syfovre-and-astellas-izervay-a-comparison-of-geographic-atrophy-treatments\/","title":{"rendered":"Comparing Apellis\u2019 Syfovre and Astellas\u2019 Izervay: A Comparison of Geographic Atrophy Treatments"},"content":{"rendered":"

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Comparing Apellis’ Syfovre and Astellas’ Izervay: A Comparison of Geographic Atrophy Treatments<\/p>\n

Geographic atrophy (GA) is a progressive and irreversible form of age-related macular degeneration (AMD) that leads to the loss of central vision. It affects millions of people worldwide and is a significant cause of visual impairment in the elderly population. In recent years, several treatment options have emerged to address this condition, including Apellis’ Syfovre and Astellas’ Izervay. In this article, we will compare these two treatments to help patients and healthcare professionals make informed decisions.<\/p>\n

1. Mechanism of Action:
\nSyfovre and Izervay both target the complement system, a part of the immune system involved in inflammation and tissue damage. Syfovre is an intravitreal injection that inhibits the complement factor C3, while Izervay is an oral medication that inhibits the complement factor C5. By targeting different components of the complement system, these treatments aim to reduce inflammation and slow down the progression of GA.<\/p>\n

2. Clinical Trials:
\nBoth Syfovre and Izervay have undergone rigorous clinical trials to evaluate their safety and efficacy. Apellis conducted the Phase 3 DERBY and OAKS trials for Syfovre, involving over 1,800 patients with GA. The results showed a significant reduction in the rate of GA progression compared to placebo. Astellas conducted the Phase 3 SEQUOIA trial for Izervay, which included over 1,300 patients. The trial demonstrated a statistically significant reduction in GA lesion growth compared to placebo.<\/p>\n

3. Administration:
\nOne key difference between Syfovre and Izervay is their route of administration. Syfovre is administered as an intravitreal injection, meaning it is injected directly into the eye by a healthcare professional. On the other hand, Izervay is an oral medication that can be taken at home. The difference in administration may influence patient preference and convenience.<\/p>\n

4. Safety Profile:
\nBoth Syfovre and Izervay have shown acceptable safety profiles in clinical trials. The most common adverse events reported with Syfovre were conjunctival hemorrhage, cataract, and eye pain. Izervay’s most common adverse events included nasopharyngitis, upper respiratory tract infection, and diarrhea. It is important to note that individual patient experiences may vary, and it is crucial to consult with a healthcare professional for personalized advice.<\/p>\n

5. Cost and Accessibility:
\nThe cost and accessibility of these treatments may also be factors to consider. As Syfovre is administered as an intravitreal injection, it may require more frequent visits to a healthcare professional, potentially increasing the overall cost. Izervay, being an oral medication, may offer greater convenience and potentially lower costs associated with administration.<\/p>\n

6. Availability:
\nSyfovre received approval from the U.S. Food and Drug Administration (FDA) in October 2021 for the treatment of GA. Izervay received approval from the European Medicines Agency (EMA) in July 2021 for the same indication. The availability of these treatments may vary depending on the region, and it is essential to consult with local healthcare providers for specific information.<\/p>\n

In conclusion, both Apellis’ Syfovre and Astellas’ Izervay offer promising treatment options for geographic atrophy. They target different components of the complement system and have shown efficacy in reducing the progression of GA. Factors such as administration route, safety profile, cost, and availability may influence the choice between these treatments. Patients should consult with their healthcare professionals to determine the most suitable option based on their individual needs and circumstances.<\/p>\n